Even without the “muscle twitch” at the end, I can easily see where they can go with Mass Effect 4.
More on the catalyst-being.
More on the original creators.
For all we know, since Mass Effect takes place only in on Galaxy, the original creators might have made their “escape” to another galaxy, to only now return once they have detected the energy wave/signature the device set off.
What dimension were these ravengers hiding in between these cycles? What other secrets might be found within? Did the energy wave/signature effect that space as well?